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Table 2 Results from Quantitative RT-PCR assays in pt #12 (the test patient)

From: Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study

Gene identification

Gene function

2-ΔΔCt

BAK1

Hs00832876_g1

Pro-apoptosis

36.1

BAX

Hs00751844_s1

Pro-apoptosis

5.5

BCL2

Hs00608023_m1

Anti-apoptosis

3.2

BIM

Hs00708019_s1

Pro-apoptosis

4.4

BCL2L14

Hs00373302_m1

Pro-apoptosis

21.6

BIRC1

Hs01847653_s1

Anti-apoptosis

10.7

BIRC4

Hs00745222_s1

Anti-apoptosis

8.1

BIRC8

Hs01057786_s1

Anti-apoptosis

521.7

BNIP3

Hs00969291_m1

Pro-apoptosis

15.7

BOK

Hs00261296_m1

Pro-apoptosis

5.4

CASPASE-5

Hs00362072_m1

Pro-apoptosis

18.2

DEDD2

Hs00370206_m1

Pro-apoptosis

2.8

HRK

Hs00705213_s1

Pro-apoptosis

338.8

LTA

Hs99999086_m1

Pro-apoptosis

13.1

LTB

Hs00242739_m1

Pro-apoptosis

7.1

TNFRSF1A

Hs01042313_m1

Pro-apoptosis

3.6

TRAIL

Hs00234356_m1

Pro-apoptosis

3.8

TRADD

Hs00601065_g1

Pro-apoptosis

3.4

BCL2L10

Hs00368095_m1

Pro-apoptosis

0.32

BIRC5

Hs00977611_g1

Anti-apoptosis

0.41

BIRC7-LIVIN

Hs00223384_m1

Anti-apoptosis

0.38

  1. 2-ΔΔCt lists how many times a gene is up- or de-regulated in bone marrow after ATO + ascorbic acid after treatment versus before therapy.