Diagnostic performance of hnRNP K and serum AFP in detection of HCC. The diagnostic accuracy of hnRNP K and AFP, in terms of sensitivity and specificity, are presented by receiver operating characteristic (ROC) curve analysis. In figures 3B and 3 C, corresponding to hnRNP K and AFP, the area under the curve for hnRNP K is markedly better than for the AFP in detecting early HCC. (A) ROC curve of hnRNP K in detection of HCC from cirrhosis (AUC = 0.89, Sen = 93.33%, Spe = 75%). (B) ROC curve of hnRNP K in detection of early HCC from late HCC (AUC = 0.75, Sen = 66.67%, Spe = 84%). (C) ROC curve of serum AFP in detection of early HCC from late HCC (AUC = 0.60). (Sen = 64.29%, Spe = 56%, cut-off value ≥ 100 ng/mL; Sen = 64.29, Spe = 40%, cut-off value ≥ 400 ng/mL). the two cut-off points of AFP are indicated with arrow.