Table 2 Echocardiographic parameters of patients and controls
From: Tissue doppler echocardiography detects preclinical markers of cardiac lesion in MDS patients
Controls(14) | NT-MDS(21) | T-MDS(13) | P value | |
|---|---|---|---|---|
Baseline demographics and characteristics | ||||
Age (year) | 72.4 ± 8 (58–84) | 70.3 ± 14 (47–88) | 65.2 ± 20 (27–90) | NS |
Gender (m/f) | (6/8) | (7/14) | (6/7) | |
Body weigth (kg) | 66.0 ± 11.9 (46 – 83) | 63.7 ± 10.1 (43.6 – 91.3) | 64.9 ± 10.1 (49.3 – 90) | NS |
Height (m) | 1.59 ± 0.09 (1.45 – 1.75) | 1.57 ± 0.07 (1.46 – 1.72) | 1.59 ± 0.08 (1.45 – 1.70) | NS |
BSA (m 2 ) | 1.68 ± 0.16 (1.42 – 1.98) | 1.64 ± 0.15 (1.33 – 2.01) | 1.67 ± 0.15 (1.4 – 2.01) | NS |
BMI (kg/m 2 ) | 26.2 ± 5.7 (19.1 – 36.9) | 25.8 ± 2.9 (20.5 – 32.3) | 25.5 ± 3.7 (21.4 – 32.7) | NS |
HR (bpm) | 75.8 ± 5.4 (66–83) | 77.6 ± 1.4 (66–88) | 78.4 ± 2.2(65–90) | NS |
SBP (mmHg) | 139.2 ± 19 (110–180) | 121.8 ± 16 (100–150) | <0.02 | |
DBP (mmHg) | 77.9 ± 12 (60–108) | 70 ± 9.6 (60–90) | NS | |
Hb (g/dL) | 9.85 ± 1.8 (6.6 - 12.7) | 6.5 ± 1.7 (3.8 - 9.9) | <0.001 | |
Ferritin (ng/mL) | 298.8 ± 234 (22.4 a 850) | 2269 ± 1931 (223 a 7101) | <0.001 | |
Chamber quantification and ejection fraction of patients and controls | ||||
LVDD (mm) | 46.0 ± 4.7 (40–57) | 48.5 ± 3.9 (41–56) | 49.3 ± 6.6 (40–64) | NS |
LVSD (mm) | 26.9 ± 4.9 (19–39) | 27.7 ± 3.7 (22–37) | 29.5 ± 6.8 (23–50) | NS |
IVS (mm) | 8.9 ± 2.3 (6–16) | 8.5 ± 0.9 (7–11) | 8.9 ± 1.4 (7–12) | NS |
LVPW (mm) | 8.5 ± 1.7 (6–13) | 8.4 ± 0.7 (7–10) | 8.8 ± 1.4 (7–12) | NS |
MASS (g) | 165.9 ± 61,0 (79–326) | 173.8 ± 34.1 (116–249) | 165.9 ± 61.0 (90–321) | NS |
MASS index (g/m 2 ) | 101.3 ± 37 (55.6 - 185) | 106 ± 18 (73–140.7) | 110 ± 37.1 (56.2 - 198) | NS |
EF%TEI | 71.8 ± 7.6 (58.2 - 89) | 71.9 ± 6.5 (58.8 - 80.1) | 69.8 ± 9.3 (43.6 - 83.9) | NS |
FS (%) | 41.4 ± 6.8 (31.2 - 58) | 41.6 ± 5.7 (31–48.7) | 39.4 ± 7.2 (22–53) | NS |
LA (mm) | 32 ± 4.2 (27–44) | 33.4 ± 4.2 (28–43) | 36.5 ± 4.9 (31–46) | <0.04* |
EF%SIM | 67.7 ± 7.3 (50.1 - 81.3) | 66.2 ± 4.8 (55.2 - 76.1) | 64.7 ± 5.4 (50.7 - 70.8) | NS |
LVEDV (ml) | 65.5 ± 18 (37–105) | 85.1 ± 29.9 (44–169) | 92.8 ± 36.1 (49–189) | <0.05* |
LVESV (ml) | 20.5 ± 6.2 (10–28) | 28.7 ± 11.9 (12.5 - 65) | 33.8 ± 19.7 (15–93) | <0.04* |
LAV (ml) | 39.1 ± 14.5 (17–69) | 43.5 ± 10.3 (25–64) | 59.8 ± 24.8 (29–120) | <0.006** |
LAV index (mL/m 2 ) | 22.8 ± 8 (10.5 - 39.6) | 26.5 ± 5.2 (15.9 - 34.8) | 35.9 ± 15 (18.8 - 70.9) | <0.004** |
Doppler parameters (transmitral and myocardial tissue) and strain of patients and controls | ||||
Evel(cm/s) | 77.2 ± 13.2 (55.4 - 105) | 89.6 ± 20 (63–128) | 96.6 ± 14.2 (68.5 - 116) | <0.02* |
Avel(cm/s) | 94.3 ± 18 (68.6 - 137.3) | 100.2 ± 19 (68.5 - 131) | 100.6 ± 27 (52.8 - 145) | NS |
E/A | 0.83 ± 0.2 (0.6 - 1.2) | 0.9 ± 0.2 (0.6 - 1.4) | 1.0 ± 0.26 (0.64 - 1,6) | NS |
Em(cm/s) | 8.6 ± 3.2 (4.1 - 14) | 9.3 ± 2.4 (5.4 - 14) | 10.4 ± 2.5 (7.5 a 14.8) | NS |
E/Em | 10 ± 3.4 (5.3 - 16.2) | 10.3 ± 3,9 (5.6 - 20) | 9.7 ± 2.9 (5.9 - 14.4) | NS |
LV-Sm(cm/s) | 6.5 ± 1.3 (5.1 - 9.5) | 7.9 ± 1.3 (5.5 - 10.8) | 7.8 ± 1.3 (6–10,3) | <0.02* |
RV-Sm(cm/s) | 10.1 ± 0.7 (9.1 - 11) | 11.4 ± 3.3 (7.6 - 19) | 12.3 ± 1,5 (9.8 - 14,7) | NS |
TAPSE(mm) | 24.9 ± 4.2 (20–33) | 28.2 ± 5.3 (21–39) | 28.9 ± 5 (22–40) | NS |
VD basal(mm) | 30.1 ± 6.4 (22–48) | 31.7 ± 4 (24–41) | 31.5 ± 4 (23–39) | NS |
ST2DL (%) | −19.9 ± 2.7 (−24 to −13) | −20.7 ± 2.5 (−25 to −16,8) | −20.9 ± 1.4 (−23 to - 18,6) | NS |