Figure 3From: BCR-ABL1-independent PI3Kinase activation causing imatinib-resistanceBCR-ABL1 signalling cascades. BCR-ABL1 induces activation of JAK2/STAT5, RAS/RAF/ERK and PI3K/AKT1/mTOR signalling pathways. SRC kinase family members may interact with BCR-ABL1 leading to mutual activation. The scheme has been adopted [11, 18, 19]. RPS6 is a downstream target of AKT1/mTOR/p70S6K.Back to article page