Figure 3

Synergism of sequence-dependent cytotoxicity between paclitaxel and gefitinib. Points, mean values of three different experiments. ○ T → G, paclitaxel followed by gefitinib. □ G → T, gefitinib followed by paclitaxel. △ T + G, concomitant paclitaxel and gefitinib. The sequence T → G produced the most potent cytotoxic growth inhibition. The T → G sequence resulted in a synergistic effect.