Table 2 DNA repair polymorphisms in the patient's pre- and post-transplantation (AML) cells and donor's cells
Polymorphism | DNA repair mechanism | Patient cells (pre-transplantation) | AML cells (post-transplantation) | Donor cells |
|---|---|---|---|---|
XPA A23G | NER | Homozygous for optimal DRC | Homozygous for optimal DRC | Homozygous for optimal DRC |
XPD Lys751Gln | NER | Heterozygous deficient DRC | Homozygous for deficient DRC | Homozygous for deficient DRC |
XRCC1 Ar399Gln | BER | Homozygous for optimal DRC | Homozygous for optimal DRC | Homozygous for optimal DRC |
XRCC3 Thr243Met | HRR | Heterozygous for deficient DRC | Homozygous for deficient DRC | Homozygous for deficient DRC |
RAD51 G135C | HRR | Homozygous for optimal DRC | Homozygous for optimal DRC | Homozygous for optimal DRC |