From: Endothelial progenitor cell biology in disease and tissue regeneration
Surface Markers | Function | Cell Expression |
---|---|---|
CD34 | Glycoprotein important for cell-cell adhesion, maintenance of stem cells in bonemarrow, mediates attachment of leukocytes to high endothelial venules [57] | Hemangioblasts, Endothelial Progenitor Cells, Vascular Endothelial Cells [10] |
VEGFR-1 (Flt1) | Tyrosine kinase receptor for VEGF A and B, important for endothelial cell assembly into vessels [58] | MAPC, Myelo/Monocytic Progenitors, Vascular Endothelial Cells [58] |
VEGFR-2 (Flk1, KDR) | Tyrosine kinase receptor for VEGF A,C,D,&E, critical for hematopoietic and endothelial cell development, principal mediator of VEGF-A mitogenic and pro-migration ability [59] | Hemangioblasts, Endothelial Progenitor Cells, MAPC, Myelo/Monocytic Cells, Vascular Endothelial Cells, Lymphatic Endothelial Cells [10] |
CD133 (Prominin 1) | Membrane glycoprotein, function unknown, serves as a marker for hematopoietic and endothelial progenitor cells [60] | Hematopoietic Cells, Endothelial Progenitor Cells [10] |
CD45 | Protein tyrosine phosphatase, important for lymphocyte activation via LCK and FYN [61] | Cells of Hematopoietic System [61] |
VE-cadherin | Calcium dependent glycoprotein, intercellular junction protein necessary for proper vascular development [62] | Mature Endothelial Cells [62] |
vWF | Secreted glycoprotein important for platelet aggregation [63] | Produced by Endothelial Cells and Megakaryocytes, Stored in Platelets [10, 63] |