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Figure 4 | Journal of Hematology & Oncology

Figure 4

From: Generation of diffuse large B cell lymphoma-associated antigen-specific Vα6/Vβ13+T cells by TCR gene transfer

Figure 4

The use of two TCR vector cassettes results in differential expression in human CD3+T cells. TCR gene-transduced CD3+T cells were stained with a TCR Vβ13-specific antibody and analyzed by flow cytometry. The numbers indicate the percentage of TCR Vβ13-positive cells. A) Human CD3+T cells transferred with empty vector as a negative control for exogenous TCR Vβ13 expression. B) Human CD3+T cells transferred with TCR Vβ13-IRES-TCR Vα6 recombinant plasmid were stained with a TCR Vβ13-specific antibody 48 h after transduction. C) Human CD3+T cells transferred with TCR Vα6-IRES-TCR Vβ13 recombinant plasmid were stained with a TCR Vβ13-specific antibody 48 h after transduction. The TCR Vβ13 gene specific for DLBCL exhibited higher expression in TCR gene-transferred CD3+T cells when the βIα vector construct was used.

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