Table 1 Literature review of ring 18 cases in acute myelogenous leukemia
From: Ring chromosome 18 abnormality in acute myelogenous leukemia: the clinical dilemma
Karyotype [Number of cells] | Antecedent disease | Disease | Treatment | Followup | Reference |
|---|---|---|---|---|---|
45, XY, der(1)t(1;11)(p36;q23), -11, dmin(18)46, XY, r(18), dmin(1) [NA]/46, WY, dmin(1) | MDS | AML-M4 | ARA-C | Died | Michalova et al[10] |
46, XX, r18(p11q21) [NA]/46, XX | Hodgkin's disease | NA | NA | NA | Lee et al[4] |
46, XY, r(18)(p11q23)[9%] | NA | AML-M4 | NA | 18+months | Testa et al[5] |
43-46, XX, -3, -5, -7, +8, r(18), +20, dmin[cp19]/46, XX[1] | Multiple myeloma | AML | VAD MP VMCP VBAP | NA | Sawyer et al[11] |
r(18) and r(20) present. Full karyotype not available | NA | AML | NA | NA | Gisselsson et al[12] |
47, +21, r(?18)[31] | NA | AML-either M1 or M2 | NA | NA | Fitzgerald et al[13] |
39-44, Y, der(X)t(X;9) (p11.2;?q32), del(1)(p13p32), t(1;10)(p21;q26), der(5)t(X;5)(p11.2;q11), -9, der(?16)r(16; 18)(?;?q11?q12), der(17)t(9;17)(?;p11), -18[cp3] | NA | tAML | NA | NA | Mrozek et al[14] |
44, XX, del(2p), del(5q), - 7, - 9, - 14, der(l7]<i(l7p)?>, -18, r(18), - 21, + 22, + mar.variations [21] | NA | AML-M4 | NA | NA | GFCH[15] |
Ring 18 present but karyotype not available so unclear if this is a sole abnormality | NA | NA | NA | NA | Schoch et al[16] |
45, XX, -7. r(18)[15] | NA | AML-M6 | NA | Lost to followup | Gibbons et al[17] |