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Table 3 Observations in the immunocompromised and the immunocompetent cohorts during Sepsis, Severe Sepsis and Septic Shock

From: Plasma protein C levels in immunocompromised septic patients are significantly lower than immunocompetent septic patients: a prospective cohort study

Variables

Sepsis

Severe Sepsis

Septic Shock

 

Immuno-compromised

Immuno-competent

Immuno-compromised

Immuno-competent

Immuno-compromised

Immuno-competent

'n'§

7

8

11

6

2

3

Age (Range)

62 (45-81)

56 (22-72)

64 (57-74)

53 (22-72)

64

65

Protein C level in μg/ml (CL Ж )

2.59*

(1.98- 3.21)

3.64*

(2.83- 4.45)

2.27**

(1.63- 2.9)

4.19**

(2.87- 5.52)

1.23

2.79

SOFA score

(CL Ж )

2.9

(0.9- 4.7)

2

(0.7- 3.3)

4.6

(3.5- 5.6)

4.3

(2.4- 6.3)

12.5

8.3

APACHE II score (CL Ж )

14.6***

(13.5- 15.6)

8.5***

(4.8- 12.2)

17.6

(15.7- 19.6)

14.3

(10.3- 18.4)

28

22

Fibrinogen level in g/l (CL Ж )

5.41

(3.34- 7.49)

5.9

(2.19- 9.61)

5.54

(3.63- 7.45)

5.13

(2.01- 8.24)

8.65

7.9

WBC (× 10 9 /l)

4.94

13.8

0.5

17.6

0.9

31.2

Platelets (× 10 9 /l)

88.3

412.4

21.5

267.5

77.5

243.3

PT Φ

12δ

10.9δ

13.1

13.2

16

16

Bilirubin ξ

(in μmol/l)

18.9Ï€

11.5Ï€

18.4ω

17.8ω

31.5

29

  1. * p = 0.03, 95% CI (Mean Difference) = -1.97 to -0.1 and ** p = 0.01, 95% CI (Mean Difference) = -3.28 to -0.57, P value for difference in the Protein C levels between immunocompromised group and immunocompetent group during sepsis and severe sepsis respectively.
  2. *** p = 0.006, P value for difference in APACHE II scores between immunocompromised group and immunocompetent group, when compared during 'sepsis'.
  3. PT Φ - Mean Prothrombin time (seconds). Normal reference range for the laboratory is 9-12 seconds.
  4. δ p = 0.1, P value for difference in mean prothrombin time between two groups during sepsis.
  5. Bilirubin ξ - Normal reference range for the laboratory is 5-17 μmol/l. π p = 0.1; ω p = 0.9; P value for difference in mean bilirubin levels between two groups during sepsis and severe sepsis.
  6. p values for the septic shock cohort have not been provided because of the small sample numbers.
  7. 'n'§- Number of patients in each of the septic category. (Patients could be in more than one category depending on whether they developed sepsis, severe sepsis or septic shock. Hence, total number of septic episodes is more than total number of patients.)
  8. CLЖ - Confidence limits