Table 2 Ezatiostat Hydrochloride Liposomes for Injection Treatment Administration
Phase 1 | |||
|---|---|---|---|
Doase Cohort (mg/m2) | # of Patients | Total # Cycles Administered | Median # of Cycles per Patient (Range) |
50 | 6 | 16 | 3 (1–5) |
100 | 3 | 10 | 4 (2–4) |
200 | 3 | 19 | 7 (4–8) |
400 | 7 | 36 | 8 (1–8) |
600 | 7 | 32 | 5 (1–8) |
TOTAL | 26 | 113 | 4 (1 – 8) |
Phase 2 | |||
Treatment (600 mg/m 2 ) | # of Patients | Total # Cycles Administered | Median # of Cycles per Patient (Range) |
Dose Schedule 1 | 10 | 93 | 8 (4 – 17) |
Dose Schedule 2 | 18 | 117 | 4 (1 – 19) |
TOTAL | 28 | 210 | 7 (1 – 19) |