Table 3 Immunohistochemical and molecular features of 50 cases of ALK-DLBCL reported in the literature
From: ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature
Number studied | Number positive/weak | % | |
|---|---|---|---|
Immunohistochemistry | |||
ALK | 50 | 50 | 100 |
Cytoplasmic | 43 | 86 | |
Nuclear | 6 | 12 | |
Other | 1 | 2 | |
VS38c/CD138/MUM1 | 39 | 39 | 100 |
EMA | 38 | 37 | 97 |
CD45 | 27 | 19/2 | 78 |
CD4 | 40 | 11/5 | 40 |
CD57 | 24 | 3/5 | 33 |
Perforin | 24 | 2 | 8 |
CD20 | 44 | 4/1 | 11 |
CD79a | 44 | 6/2 | 18 |
CD30 | 45 | 5 | 11 |
EBV | 17 | 0 | 0 |
HHV8 | 2 | 0 | 0 |
Molecular studies | |||
ALK gene rearrangement | 24 | 24 | 100 |
Clathrin/ALK | 18 | 75 | |
Nucleophosmin/ALK | 4 | 16 | |
Other rearrangements | 2 | 8 | |
IgH gene rearrangement | 20 | 17 | 85 |
TCR gene rearrangement | 4 | 1 | 25 |
EBER CISH | 12 | 0 | 0 |