Figure 4From: Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapyProposed mechanism of action of LA. In this model, the ability of LA to suppress cell proliferation and induce apoptosis in HL-60 cells is hypothesized to involve (A) disruption of cell cycle control, (B) perturbation in apoptogenic/anti-apoptotic (bax/bcl-2) regulatory protein expression and translocation of mitochondrial AIF and cytochrome c (Cyt C) from mitochondria to nucleus and promoting the caspase-independent induction of apoptosis.Back to article page