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Table 1 Reports of antiandrogen withdrawal

From: A dramatic, objective antiandrogen withdrawal response: case report and review of the literature

Author

Antiandrogen agent(s)

No. of Patients

No. of patients with 50% PSA decline

Duration of Anti-androgen therapy (Months)

Duration of AAWR (Months)

Kelly[5]

Flutamide

3

2

5–17

2–5

Collinson[17]

Flutamide

1

1

12

12

Scher[6]

Flutamide

36

10

NS

5*

Scher[15]

Flutamide

57

16

16

5.6

Dupont[7]

Flutamide†

40

32

5–7

14.5

Figg[16]

Flutamide

21

7

28

3.7

Sartor[18]

Flutamide†

29

14

Median: 27*

8

Herrade[8]

Flutamide

39

11

Median: 19*

3.3

Small[9]

Flutamide

82

12

Median: 21.5*

3.5

Small[10]

Bicalutamide

1

1

32

2

Nieh[19]

Bicalutamide

3

2

24–35

2–4

Schellhammer [11]

Flutamide/Bicalutamide‡

22

8

16 months combined with LHRH agonist

NS

Small[14]

Flutamide/Bicalutamide/Nilutamide

132

15

NS

5.9

Gomella[12]

Nilutamide

1

1

11

3

Huan[13]

Nilutamide††

2

2

10 and 15

7 and 6

  1. NS = not stated
  2. * indicates median
  3. † Adjuvant treatment with aminoglutamide and hydrocortisone
  4. ‡ 4 patients assessed for objective response at 12 weeks: 2 has stable disease
  5. †† One patient was treated with flutamide, and then cyproterone before nilutamide; Another patient were treated with combined goserelin and nilutamide